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Antimicrobial Agents and Chemotherapy, March 2000, p. 773-774, Vol. 44, No. 3
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Comparative Activities of Ciprofloxacin and Levofloxacin against Streptococcus pneumoniae in an In Vitro Dynamic Model

Stephen H. Zinner,* Kelly Simmons, and Deborah Gilbert

Department of Medicine, Rhode Island Hospital, Roger Williams Medical Center, Brown University, Providence, Rhode Island

Received 8 March 1999/Returned for modification 18 September 1999/Accepted 1 December 1999

The activities of levofloxacin (500 mg every 24 h) and ciprofloxacin (750 mg every 12 h) against six pneumococcal isolates in an in vitro dynamic model were compared. For one strain, levofloxacin reduced the inoculum by over 4 log CFU/ml and ciprofloxacin reduced the inoculum by over 2 log CFU/ml. For four isolates, both drugs reduced inocula by 4 log CFU/ml within 6 h, suggesting that this dose of ciprofloxacin should be as effective as levofloxacin against these pneumococci.

* Corresponding author. Present address: Department of Medicine, Mount Auburn Hospital, 330 Mount Auburn St., Cambridge, MA 02238. Phone: (617) 499-5421. Fax: (617) 499-5593. E-mail: szinner{at}caregroup.harvard.edu.

Antimicrobial Agents and Chemotherapy, March 2000, p. 773-774, Vol. 44, No. 3
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Schentag, J. J, Meagher, A. K, Forrest, A. (2003). Fluoroquinolone AUIC Break Points and the Link to Bacterial Killing Rates: Part 1: In Vitro and Animal Models. The Annals of Pharmacotherapy 37: 1287-1298 [Abstract] [Full Text]  
  • Zelenitsky, S. A., Ariano, R. E., Iacovides, H., Sun, S., Harding, G. K. M. (2003). AUC0-t/MIC is a continuous index of fluoroquinolone exposure and predictive of antibacterial response for Streptococcus pneumoniae in an in vitro infection model. J Antimicrob Chemother 51: 905-911 [Abstract] [Full Text]  


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