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Antimicrobial Agents and Chemotherapy, March 2000, p. 778-779, Vol. 44, No. 3
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Postantibiotic Effects and Bactericidal Activities of Clarithromycin-14-Hydroxy-Clarithromycin, versus Those of Amoxicillin-Clavulanate, against Anaerobes

Rose Jung,1 Chad R. Messick,2 Susan L. Pendland,3,* Eljim P. Tesoro,3 Karen J. Losendahl,3 Christopher A. Schriever,3 and Larry H. Danziger3

Department of Pharmacy Practice, University of Colorado Health Science Center, Denver, Colorado1; Microbiology Research Laboratory, Department of Pharmacy Practice, The University of Illinois at Chicago, Chicago, Illinois3; and Veterans Affairs Cooperative Study Program, Clinical Research Pharmacy Coordinating Center, Albuquerque, New Mexico2

Received 10 February 1999/Returned for modification 19 September 1999/Accepted 1 December 1999

The bactericidal activities and postantibiotic effects (PAE) of clarithromycin-14-hydroxy-clarithromycin and amoxicillin-clavulanate against Bacteroides fragilis and Peptostreptococcus anaerobius were determined. A concentration of twice the MIC resulted in bactericidal activity against four of four and three of four organisms at 24 h with clarithromycin-14-hydroxy-clarithromycin and amoxicillin-clavulanate, respectively. The PAE of clarithromycin-14-hydroxy-clarithromycin was 1.44 to 3.20 h, compared to the less than 1 h of amoxicillin-clavulanate. Clarithromycin-14-hydroxy-clarithromycin possesses good activity against susceptible anaerobes.

* Corresponding author. Mailing address: The University of Illinois at Chicago College of Pharmacy, Department of Pharmacy Practice (M/C 886), 833 South Wood St., Chicago, IL 60612. Phone: (312) 996-8639. Fax: (312) 413-1797. E-mail: Pendland{at}uic.edu.

Antimicrobial Agents and Chemotherapy, March 2000, p. 778-779, Vol. 44, No. 3
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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