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Antimicrobial Agents and Chemotherapy, March 2000, p. 790-793, Vol. 44, No. 3
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Characterization of the Tn916-like Transposon Tn3872 in a Strain of Abiotrophia defectiva (Streptococcus defectivus) Causing Sequential Episodes of Endocarditis in a Child

Claire Poyart,1,2,* Gilles Quesne,1,2 Philippe Acar,3 Patrick Berche,2 and Patrick Trieu-Cuot1,2

Laboratoire Mixte Pasteur-Necker de Recherche sur les Streptocoques et Streptococcies, Faculté de Médecine Necker-Enfants Malades,1 Unité INSERM 411,2 and Service de Cardiologie Infantile Pédiatrique, Hôpital Necker-Enfants Malades,3 75730 Paris Cedex 15, France

Received 13 August 1999/Returned for modification 11 October 1999/Accepted 9 December 1999

Clinical blood isolates from three sequential episodes of endocarditis occurring over a 6-month period in a child with a malformative cardiopathy were investigated. All isolates identified as Abiotrophia defectiva were resistant to erythromycin-clindamycin and to tetracycline-minocycline, due to the presence of sequences homologous to the erythromycin resistance gene ermB and to the tetracycline resistance gene tet(M), respectively. These resistance genes were located on a chromosomally borne composite Tn916-related transposon. These results demonstrate the involvement of conjugative transposons in the dissemination of antibiotic resistance in the genus Abiotrophia.

* Corresponding author. Mailing address: Laboratoire Mixte Pasteur-Necker de Recherche sur les Streptocoques et Streptococcies, Faculté de Médecine Necker-Enfants Malades, 75730 Paris Cedex 15, France. Phone: (33) (1) 40 61 56 79. Fax: (33) (1) 40 61 55 92. E-mail: cpoyart{at}pasteur.fr.

Antimicrobial Agents and Chemotherapy, March 2000, p. 790-793, Vol. 44, No. 3
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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