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Antimicrobial Agents and Chemotherapy, March 2000, p. 802-805, Vol. 44, No. 3
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Comparative In Vitro Activities of Ciprofloxacin, Gemifloxacin, Grepafloxacin, Moxifloxacin, Ofloxacin, Sparfloxacin, Trovafloxacin, and Other Antimicrobial Agents against Bloodstream Isolates of Gram-Positive Cocci

Dwight Hardy,1 Daniel Amsterdam,2 Lionel A. Mandell,3 and Coleman Rotstein3,*

Department of Microbiology and Immunology, University of Rochester, Rochester,1 and Department of Microbiology, Medicine, and Pathology, School of Medicine, University at Buffalo, and Erie County Medical Center, Buffalo,2 New York, and Division of Infectious Diseases, McMaster University, Henderson Site, Hamilton Health Sciences Corporation, Hamilton, Ontario, Canada3

Received 13 July 1999/Returned for modification 17 September 1999/Accepted 9 December 1999

The in vitro activity of gemifloxacin against 316 bloodstream isolates of staphylococci, pneumococci, and enterococci was compared with the activities of six fluoroquinolones and three other antimicrobial agents. Of the antimicrobial agents tested, gemifloxacin was the most potent against penicillin-intermediate and -resistant pneumococci, methicillin-susceptible and -resistant Staphylococcus epidermidis isolates, and coagulase-negative staphylococci.

* Corresponding author. Mailing address: McMaster Medical Unit, Henderson Site, Hamilton Health Sciences Corp., 711 Concession St., Hamilton, Ontario L8V 1C3, Canada. Phone: (905) 574-3301. Fax: (905) 575-7320. E-mail: crotstei{at}fhs.mcmaster.ca.

Antimicrobial Agents and Chemotherapy, March 2000, p. 802-805, Vol. 44, No. 3
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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