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Antimicrobial Agents and Chemotherapy, April 2000, p. 1059-1061, Vol. 44, No. 4
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Pronounced Postantibiotic Effect of Quinupristin-Dalfopristin in Static Cultures of Staphylococcus aureus: an Effect Not Seen with Other Antibiotics

Esther Pfeil and Bernd Wiedemann*

Pharmazeutische Mikrobiologie, Rheinische Friedrich-Wilhelms-Universität Bonn, D53115 Bonn, Germany

Received 14 December 1998/Returned for modification 29 April 1999/Accepted 18 January 2000

Quinupristin-dalfopristin produced postantibiotic effects (PAEs) on exponentially growing (log phase) and nongrowing (lag phase) cultures of 0.4 to 6.9 h. PAEs of the other antibiotics tested were 0.5 to 1.9 h, determined with exponentially growing cultures. None of these antibiotics show a PAE on lag-phase bacteria.

* Corresponding author. Mailing address: Pharmaceutical Microbiology, University Bonn, Meckenheimer Allee 168, D 53115 Bonn, Germany. Phone: 0049-228-735272. Fax: 0049-228-735267. E-mail: b.wiedemann{at}uni-bonn.de.

Antimicrobial Agents and Chemotherapy, April 2000, p. 1059-1061, Vol. 44, No. 4
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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