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Antimicrobial Agents and Chemotherapy, April 2000, p. 1070-1074, Vol. 44, No. 4
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Nucleotide Sequence of the blaRTG-2 (CARB-5) Gene and Phylogeny of a New Group of Carbenicillinases

Daniele Choury,1,* Marie-France Szajnert,2 Marie-Laure Joly-Guillou,3 Kemal Azibi,2 Marc Delpech,1 and Gérard Paul4

Laboratoire de Biologie Moléculaire des Cellules Eucaryotes,1 INSERM U129,2 and Laboratoire de Recherche en Microbiologie,4 UFR Cochin Port-Royal, 75014 Paris, and UFR Xavier-Bichat, 75018 Paris,3 France

Received 27 July 1999/Returned for modification 16 November 1999/Accepted 30 December 1999

We determined the nucleotide sequence of the bla gene for the Acinetobacter calcoaceticus beta -lactamase previously described as CARB-5. Alignment of the deduced amino acid sequence with those of known beta -lactamases revealed that CARB-5 possesses an RTG triad in box VII, as described for the Proteus mirabilis GN79 enzyme, instead of the RSG consensus characteristic of the other carbenicillinases. Phylogenetic studies showed that these RTG enzymes constitute a new, separate group, possibly ancestors of the carbenicillinase family.

* Corresponding author. Mailing address: Laboratoire de Biologie Moléculaire des Cellules Eucaryotes, UFR Cochin Port-Royal 24, rue du Faubourg Saint-Jacques, 75014 Paris, France. Phone: 00 33 1 44 41 23 47. Fax: 00 33 1 44 41 23 42. E-mail: paul{at}citi2.fr.

Antimicrobial Agents and Chemotherapy, April 2000, p. 1070-1074, Vol. 44, No. 4
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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