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Antimicrobial Agents and Chemotherapy, April 2000, p. 1078-1080, Vol. 44, No. 4
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Susceptibilities of Oral and Nasal Isolates of Streptococcus mitis and Streptococcus oralis to Macrolides and PCR Detection of Resistance Genes

Tsuneko Ono,1,* Sumiko Shiota,2 Katsuhiko Hirota,1 Ken Nemoto,1 Tomofusa Tsuchiya,2 and Yoichiro Miyake1

Department of Microbiology, Tokushima University School of Dentistry, Tokushima 770-8504,1 and Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530,2 Japan

Received 2 June 1999/Returned for modification 2 September 1999/Accepted 12 January 2000

The susceptibility of viridans group streptococci to macrolides was determined. Thirteen isolates (17%) were resistant to erythromycin. Five strains carried an erm gene that was highly homologous to that in Tn917. Four strains had mefE genes that coded erythromycin efflux ability.

* Corresponding author. Mailing address: Department of Microbiology, Tokushima University School of Dentistry, Kuramoto-cho, Tokushima 770-8504, Japan. Phone: (81-88) 633-9122. Fax: (81-88) 633-7390. E-mail: ono{at}dent.tokushima-u.ac.jp.

Antimicrobial Agents and Chemotherapy, April 2000, p. 1078-1080, Vol. 44, No. 4
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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