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Antimicrobial Agents and Chemotherapy, April 2000, p. 1081-1084, Vol. 44, No. 4
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

SHV-13, a Novel Extended-Spectrum beta -Lactamase, in Klebsiella pneumoniae Isolates from Patients in an Intensive Care Unit in Amsterdam

Meifang Yuan,1 Lucinda M. C. Hall,1 Paul H. M. Savelkoul,2 Christina M. J. E. Vandenbroucke-Grauls,2 and David M. Livermore3,*

Department of Medical Microbiology, St. Bartholomew's and The Royal London School of Medicine and Dentistry, London E1 2AD,1 and Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, London NW9 5HT3, United Kingdom, and Department of Medical Microbiology and Infection Control, University Hospital Vrije Universiteit, Amsterdam, The Netherlands2

Received 16 July 1999/Returned for modification 16 November 1999/Accepted 14 January 2000

Eleven clonally related Klebsiella pneumoniae isolates were examined. These had been isolated at an intensive care unit in Amsterdam in 1994. Their resistance was associated with a conjugative 170-kb plasmid which encoded a novel SHV beta -lactamase designated SHV-13. The SHV-13 enzyme had two substitutions compared with SHV-1: Leu35Gln and Gly238Ala. It hydrolyzed cefotaxime much more rapidly than ceftazidime or aztreonam.

* Corresponding author. Mailing address: Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, 61 Colindale Ave., London NW9 5HT, United Kingdom. Phone: 0181-200-4400, ext. 4223. Fax: 0181-200-7449. E-mail: DLivermore{at}phls.nhs.uk.

Antimicrobial Agents and Chemotherapy, April 2000, p. 1081-1084, Vol. 44, No. 4
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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