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Antimicrobial Agents and Chemotherapy, April 2000, p. 1085-1088, Vol. 44, No. 4
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Antipneumococcal Activities of GAR-936 (a New Glycylcycline) Compared to Those of Nine Other Agents against Penicillin-Susceptible and -Resistant Pneumococci

Dianne B. Hoellman,1 Glenn A. Pankuch,1 Michael R. Jacobs,2 and Peter C. Appelbaum1,*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033,1 and Department of Pathology, Case Western Reserve University, Cleveland, Ohio 441062

Received 25 June 1999/Returned for modification 26 November 1999/Accepted 16 January 2000

GAR-936, a new glycylcycline, had lower MICs (<= 0.016 to 0.125 µg/ml) for 201 penicillin- and tetracycline-susceptible and -resistant pneumococcal strains than tetracycline (<= 0.06 to 128 µg/ml), minocycline (<= 0.06 to 16.0 µg/ml), or doxycycline (<= 0.06 to 32.0 µg/ml). GAR-936 was also bactericidal against 11 of 12 strains tested at the MIC after 24 h, with significant kill rates at earlier time points.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psghs.edu.

Antimicrobial Agents and Chemotherapy, April 2000, p. 1085-1088, Vol. 44, No. 4
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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