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Antimicrobial Agents and Chemotherapy, April 2000, p. 1089-1092, Vol. 44, No. 4
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

A Canadian National Surveillance Study of Urinary Tract Isolates from Outpatients: Comparison of the Activities of Trimethoprim-Sulfamethoxazole, Ampicillin, Mecillinam, Nitrofurantoin, and Ciprofloxacin

George G. Zhanel,1,2,3,4,* James A. Karlowsky,1,2,4 Godfrey K. M. Harding,1,5 Anita Carrie,2 Tony Mazzulli,6,7 Donald E. Low,6,7 The Canadian Urinary Isolate Study Group,dagger and Daryl J. Hoban1,4

Department of Medical Microbiology, Faculty of Medicine,1 and Faculty of Pharmacy,2 University of Manitoba, and Departments of Medicine3 and Clinical Microbiology,4 Health Sciences Centre, and Department of Microbiology, St. Boniface General Hospital,5 Winnipeg, Manitoba, and Department of Microbiology, Mount Sinai and Princess Margaret Hospitals, University of Toronto,6 and Med-Chem Health Care, Ltd.,7 Toronto, Ontario, Canada

Received 17 June 1999/Returned for modification 30 December 1999/Accepted 25 January 2000

Ampicillin, trimethoprim-sulfamethoxazole, mecillinam, nitrofurantoin, and ciprofloxacin mean resistance rates for 2,000 urinary tract isolates collected from outpatients across Canada in 1998 were 41.1, 19.2, 14.7, 5.0, and 1.8%, respectively. For Escherichia coli isolates alone (n = 1,681) comparable rates were 41.0, 18.9, 7.4, 0.1, and 1.2%, respectively. The majority of E. coli isolates resistant to ampicillin, trimethoprim-sulfamethoxazole, or ciprofloxacin were susceptible (MIC, <16 µg/ml) to mecillinam.

* Corresponding author. Mailing address: Department of Microbiology, Health Sciences Centre, MS673, 820 Sherbrook St., Winnipeg, Manitoba R3A 1R9, Canada. Phone: (204) 787-4902. Fax: (204) 787-4699. E-mail: ggzhanel{at}pcs.mb.ca.

dagger For names and affiliations of members of this group, see the appendix.

Antimicrobial Agents and Chemotherapy, April 2000, p. 1089-1092, Vol. 44, No. 4
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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