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Antimicrobial Agents and Chemotherapy, April 2000, p. 1100-1101, Vol. 44, No. 4
0066-4804/00/$04.00+0

Effect of Fluconazole on the Pharmacokinetics of Doxorubicin in Nonhuman Primates

Katherine E. Warren,* Cynthia M. McCully, Thomas J. Walsh, and Frank M. Balis

Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892-1928

Received 26 February 1999/Returned for modification 23 December 1999/Accepted 18 January 2000

Antifungal prophylaxis in cancer patients who are undergoing chemotherapy is associated with prolonged neutropenia. We measured the effect of fluconazole on doxorubicin pharmacokinetics in nonhuman primates to determine if neutropenia is related to a pharmacokinetic interaction that delays the clearance of the chemotherapeutic agent. Fluconazole pretreatment had no effect on doxorubicin pharmacokinetics.

* Corresponding author. Mailing address: Pediatric Oncology Branch, Bldg. 10/Rm. 13N240, 10 Center Dr., MSC 1928, Bethesda, MD 20892-1928. Phone: (301) 496-1756. Fax: (301) 402-0575. E-mail: warrenk{at}exchange.nih.gov.

Antimicrobial Agents and Chemotherapy, April 2000, p. 1100-1101, Vol. 44, No. 4
0066-4804/00/$04.00+0


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