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Antimicrobial Agents and Chemotherapy, May 2000, p. 1352-1355, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Pharmacokinetics and Pharmacodynamics of Levofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in Human Skin Blister Fluid

Andrej Trampuz,1 Markus Wenk,2 Zarko Rajacic,1 and Werner Zimmerli1,*

Division of Infectious Diseases1 and Division of Clinical Pharmacology,2 Departments of Internal Medicine and Research, University Hospitals, Basel, Switzerland

Received 5 August 1999/Returned for modification 21 December 1999/Accepted 9 February 2000

The pharmacokinetics of levofloxacin in serum and in skin blister fluid (SBF) was determined for 20 volunteers after a single 500-mg oral dose of levofloxacin. In addition, ex vivo bactericidal activity of SBF against Streptococcus pneumoniae and Staphylococcus aureus was studied. SBF containing levofloxacin and granulocytes killed 5.2 log of Streptococcus pneumoniae bacteria and 2.0 log of Staphylococcus aureus bacteria during a 6-h incubation.

* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Internal Medicine, University Hospitals, Petersgraben 4, CH-4031 Basel, Switzerland. Phone: 41 61 265 2114. Fax: 41 61 265 3198. E-mail: werner.zimmerli{at}unibas.ch.

Antimicrobial Agents and Chemotherapy, May 2000, p. 1352-1355, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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