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Antimicrobial Agents and Chemotherapy, May 2000, p. 1356-1358, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Cerebrospinal Fluid Penetration and Pharmacokinetics of Vancomycin Administered by Continuous Infusion to Mechanically Ventilated Patients in an Intensive Care Unit

Jacques Albanèse,1 Marc Léone,1 Bernard Bruguerolle,2 Marie-Laure Ayem,1 Bruno Lacarelle,2 and Claude Martin1,*

Intensive Care Unit and Trauma Center, Nord Hospital, Marseilles University Hospital System,1 and Department of Pharmacokinetics,2 Marseilles School of Medicine, Marseilles, France

Received 22 February 1999/Returned for modification 1 December 1999/Accepted 10 February 2000

Cerebrospinal fluid (CSF) penetration and the pharmacokinetics of vancomycin were studied after continuous infusion (50 to 60 mg/kg of body weight/day after a loading dose of 15 mg/kg) in 13 mechanically ventilated patients hospitalized in an intensive care unit. Seven patients were treated for a sensitive bacterial meningitis and the other six patients, who had a severe concomitant neurologic disease with intracranial hypertension, were treated for various infections. Vancomycin CSF penetration was significantly higher (P < 0.05) in the meningitis group (serum/CSF ratio, 48%) than in the other group (serum/CSF ratio, 18%). Vancomycin pharmacokinetic parameters did not differ from those obtained with conventional dosing. No adverse effect was observed, in particular with regard to renal function.

* Corresponding author. Mailing address: Service de Réanimation Polyvalente, Hôpital Nord, 13915 Marseille Cedex 1, France. Phone: 33 4 91968650. Fax: 33 4 919682818. E-mail: cmartin{at}ap-hm.fr.

Antimicrobial Agents and Chemotherapy, May 2000, p. 1356-1358, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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