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Antimicrobial Agents and Chemotherapy, May 2000, p. 1362-1364, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Effects of the Movement of Insertion Sequences on the Structure of VanA Glycopeptide Resistance Elements in Enterococcus faecium

Ana L. C. Darini,dagger Marie-France I. Palepou, and Neil Woodford*

Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, London NW9 5HT, United Kingdom

Received 6 December 1999/Returned for modification 18 January 2000/Accepted 15 February 2000

A Tn1546-related element with IS1216V at position 8839 underwent a structural change after storage of the host strain of Enterococcus faecium at 4°C. The element acquired IS1542 at position 3932, nucleotides 8732 to 8831 were deleted, and the first 3417 nucleotides were lost and replaced by an inverted copy of the IS1216V-vanY-vanZ-inverted-repeat block from the 3' end. Insertion sequence movement is likely to play a key role in the evolution of VanA resistance elements.

* Corresponding author. Mailing address: ARMRL, CPHL, 61 Colindale Ave., London NW9 5HT, United Kingdom. Phone: 44-(0)208-200-4400, ext. 4255. Fax: 44-(0)208-358-3292. E-mail: nwoodford{at}phls.nhs.uk.

dagger Present address: Faculdade de Ciencias Farmaceuticas de Ribeirao Preto-USP, Ribeirao Preto SP, Brazil.

Antimicrobial Agents and Chemotherapy, May 2000, p. 1362-1364, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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