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Antimicrobial Agents and Chemotherapy, May 2000, p. 1370-1374, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

In Vitro Activities of LY333328 and Comparative Agents against Nosocomial Gram-Positive Pathogens Collected in a 1997 Global Surveillance Study

Michael L. Zeckel, David A. Preston,* and Bradley S. Allen

Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285

Received 19 October 1999/Returned for modification 10 December 1999/Accepted 31 January 2000

The in vitro activity of LY333328 was evaluated for 1,479 nosocomial gram-positive pathogens isolated in 12 countries during 1997. LY333328 MICs at which 90% of the isolates tested were inhibited for Enterococcus faecalis (n = 351), Enterococcus faecium (n = 100), Staphylococcus aureus (n = 593), coagulase-negative Staphylococcus species (n = 325), and Streptococcus pneumoniae (n = 110) were 1, 1, 2, 2, and 0.015 µg/ml, respectively. LY333328 demonstrated potent activity against isolates of vancomycin-resistant enterococci, oxacillin-resistant staphylococci, and penicillin-resistant pneumococci.

* Corresponding author. Mailing address: Eli Lilly and Co., Lilly Corporate Center, Drop Code 2225, Indianapolis, IN 46285. Phone: (317) 848-2052. Fax: (317) 848-2052. E-mail: ahpreston{at}mindspring.com.

Antimicrobial Agents and Chemotherapy, May 2000, p. 1370-1374, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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