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Antimicrobial Agents and Chemotherapy, May 2000, p. 1377-1380, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Comparative Killing Rates of Fluoroquinolones and Cell Wall-Active Agents

Joan C. Fung-Tomc,* Elizabeth Gradelski, Lourdes Valera, Benjamin Kolek, and Daniel P. Bonner

Department of Microbiology, Bristol-Myers Squibb Company, Wallingford, Connecticut 06492

Received 8 October 1999/Returned for modification 24 November 1999/Accepted 11 February 2000

Killing rates of fluoroquinolones, beta -lactams, and vancomycin were compared against Enterobacteriaceae, Staphylococcus aureus, pneumococci, streptococci, and Enterococcus faecalis. The times required for fluoroquinolones to decrease viability by 3 log10 were 1.5 h for Enterobacteriaceae, 4 to 6 h for staphylococci, and >= 6 h for streptococci and enterococci. Thus, the rate of killing by fluoroquinolones is organism group dependent; overall, they killed more rapidly than beta -lactams and vancomycin.

* Corresponding author. Mailing address: Bristol-Myers Squibb Company, Department of Microbiology-104, 5 Research Pkwy., Wallingford, CT 06492. Phone: (203) 677-6370. Fax: (203) 677-6771. E-mail: fungtomj{at}bms.com.

Antimicrobial Agents and Chemotherapy, May 2000, p. 1377-1380, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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