This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Domaracki, B. E.
Right arrow Articles by Venezia, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Domaracki, B. E.
Right arrow Articles by Venezia, R. A.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, May 2000, p. 1394-1396, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Vancomycin and Oxacillin Synergy for Methicillin-Resistant Staphylococci

Beth E. Domaracki, Ann M. Evans, and Richard A. Venezia*

Department of Pathology and Laboratory Medicine, Albany Medical Center, Albany, New York 12208

Received 29 July 1999/Returned for modification 26 November 1999/Accepted 17 February 2000

An increase in oxacillin activity was observed against methicillin-resistant coagulase-negative staphylococci (MRCNS) and methicillin-resistant Staphylococcus aureus (MRSA) in the presence of a sub-MIC of vancomycin. Vancomycin and oxacillin were synergistic against 14 of 21 strains of MRCNS and MRSA. A pattern of enhanced killing was also supported by time-kill studies. These results suggest that combinations of sub-MICs of vancomycin and oxacillin may have therapeutic benefits against methicillin-resistant staphylococci.

* Corresponding author. Mailing address: Department of Pathology and Laboratory Medicine, Albany Medical Center, A-22, Albany, NY 12208. Phone: (518) 262-3506. Fax: (518) 262-4337. E-mail: VENEZIR{at}MAIL.AMC.EDU.

Antimicrobial Agents and Chemotherapy, May 2000, p. 1394-1396, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Nguyen, H. M., Graber, C. J. (2009). Limitations of antibiotic options for invasive infections caused by methicillin-resistant Staphylococcus aureus: is combination therapy the answer?. J Antimicrob Chemother 0: dkp377v1-dkp377 [Abstract] [Full Text]  
  • Vignaroli, C., Biavasco, F., Varaldo, P. E. (2006). Interactions between Glycopeptides and {beta}-Lactams against Isogenic Pairs of Teicoplanin-Susceptible and -Resistant Strains of Staphylococcus haemolyticus.. Antimicrob. Agents Chemother. 50: 2577-2582 [Abstract] [Full Text]  
  • Domenech, A., Ribes, S., Cabellos, C., Taberner, F., Tubau, F., Dominguez, M. A., Montero, A., Linares, J., Ariza, J., Gudiol, F. (2005). Experimental study on the efficacy of combinations of glycopeptides and {beta}-lactams against Staphylococcus aureus with reduced susceptibility to glycopeptides. J Antimicrob Chemother 56: 709-716 [Abstract] [Full Text]  
  • Sweeney, M. T., Zurenko, G. E. (2003). In Vitro Activities of Linezolid Combined with Other Antimicrobial Agents against Staphylococci, Enterococci, Pneumococci, and Selected Gram-Negative Organisms. Antimicrob. Agents Chemother. 47: 1902-1906 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»