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Antimicrobial Agents and Chemotherapy, June 2000, p. 1739-1742, Vol. 44, No. 6
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Antileishmanial Activities of Stearylamine-Bearing Liposomes

Tuhina Dey, Khairul Anam, Farhat Afrin, and Nahid Ali*

Leishmania Group, Indian Institute of Chemical Biology, Calcutta 700032, India

Received 5 January 2000/Returned for modification 19 January 2000/Accepted 6 March 2000

Here we report the activity of liposomes comprising egg phosphatidylcholine (PC) and stearylamine (SA) against Leishmania donovani parasites. Both promastigotes and intracellular amastigotes in vitro and in vivo were susceptible to SA-PC liposomes. A single dose of 55 mg of SA-PC liposomes/animal could significantly reduce the hepatic parasite burden by 85 and 68% against recent and established experimental visceral leishmaniasis, respectively, suggesting their strong therapeutic potential.

* Corresponding author. Mailing address: Leishmania Division, Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Rd., Calcutta 700032, India. Phone: 473-3491/0492/6793. Fax: 91-33-4735197. E-mail: IICHBIO{at}GIASCL01.VSNL.NET.IN.

Antimicrobial Agents and Chemotherapy, June 2000, p. 1739-1742, Vol. 44, No. 6
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Banerjee, A., De, M., Ali, N. (2008). Complete Cure of Experimental Visceral Leishmaniasis with Amphotericin B in Stearylamine-Bearing Cationic Liposomes Involves Down-Regulation of IL-10 and Favorable T Cell Responses. J. Immunol. 181: 1386-1398 [Abstract] [Full Text]  
  • Banerjee, A., Roychoudhury, J., Ali, N. (2008). Stearylamine-bearing cationic liposomes kill Leishmania parasites through surface exposed negatively charged phosphatidylserine. J Antimicrob Chemother 61: 103-110 [Abstract] [Full Text]  
  • Pal, S., Ravindran, R., Ali, N. (2004). Combination Therapy Using Sodium Antimony Gluconate in Stearylamine-Bearing Liposomes against Established and Chronic Leishmania donovani Infection in BALB/c Mice. Antimicrob. Agents Chemother. 48: 3591-3593 [Abstract] [Full Text]  
  • Murray, H. W. (2001). Clinical and Experimental Advances in Treatment of Visceral Leishmaniasis. Antimicrob. Agents Chemother. 45: 2185-2197 [Full Text]  


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