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Antimicrobial Agents and Chemotherapy, June 2000, p. 1743-1744, Vol. 44, No. 6
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Cyclic AMP and Fluconazole Resistance in Saccharomyces cerevisiae

D. P. Kontoyiannis1,* and Steffen Rupp1,2

Department of Internal Medicine Specialties, Section of Infectious Diseases, The University of Texas M. D. Anderson Cancer Center, Houston, Texas,1 and Fraunhofer IGB, Stuttgart, Germany2

Received 30 November 1999/Returned for modification 2 February 2000/Accepted 11 March 2000

Cyclic AMP (cAMP) is involved in the stress response in Saccharomyces cerevisiae. We show that cAMP is required for resistance to fluconazole in S. cerevisiae. In addition, activation of Ras2, a regulator of cAMP generation, results in some protection from fluconazole toxicity in a fashion independent of the efflux transporter Pdr5p.

* Corresponding author. Mailing address: Department of Internal Medicine Specialties, Section of Infectious Diseases, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 47, Houston, TX 77030. Phone: (713) 792-6237. Fax: (713) 794-4351. E-mail: dkontoyi{at}notes.mdacc.tmc.edu.

Antimicrobial Agents and Chemotherapy, June 2000, p. 1743-1744, Vol. 44, No. 6
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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  • Jain, P., Akula, I., Edlind, T. (2003). Cyclic AMP Signaling Pathway Modulates Susceptibility of Candida Species and Saccharomyces cerevisiae to Antifungal Azoles and Other Sterol Biosynthesis Inhibitors. Antimicrob. Agents Chemother. 47: 3195-3201 [Abstract] [Full Text]  


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