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Antimicrobial Agents and Chemotherapy, July 2000, p. 1986-1989, Vol. 44, No. 7
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Pharmacokinetics of Zidovudine Phosphorylation in Human Immunodeficiency Virus-Positive Thai Patients and Healthy Volunteers

Yupaporn Wattanagoon,1 Kesara Na Bangchang,1 Patrick G. Hoggard,2,* Saye H. Khoo,2 Sara E. Gibbons,2 Danabhand Phiboonbhanakit,2 Juntra Karbwang,1 and David J. Back2

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand,1 and Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, L69 3GE, United Kingdom2

Received 30 August 1999/Returned for modification 23 January 2000/Accepted 3 April 2000

We assessed the pharmacokinetics of zidovudine (ZDV) in plasma and intracellular ZDV phosphate anabolites in peripheral blood mononuclear cells in Thai human immunodeficiency virus (HIV) type 1-infected patients and healthy volunteers. The plasma ZDV area under the concentration-time curve from 0 to 6 h (AUC0-6) was similar in patients and healthy volunteers (32.77 and 22.77 µmol/liter · h, respectively; confidence interval, -3.37 to 19.92). Although the concentration of ZDV triphosphate (ZDVTP) was similar in the two groups, the ZDV monophosphate (ZDVMP) AUC0-6 was significantly greater in HIV patients (1.12 pmol/106 cells) than in healthy volunteers (0.15 pmol/106 cells). In agreement with previously published data obtained with Caucasians, the significant difference in intracellular phosphorylation in Thai volunteers and HIV patients is primarily due to ZDVMP. Comparing the data from this study with the data obtained with Caucasians suggests no marked ethnic differences in ZDV phosphorylation.

* Corresponding author. Mailing address: Department of Pharmacology and Therapeutics, Ashton St., University of Liverpool, Liverpool, L69 3GE, United Kingdom. Phone: 0151 794 5565. Fax: 0151 794 5540. E-mail: patrick{at}liv.ac.uk.

Antimicrobial Agents and Chemotherapy, July 2000, p. 1986-1989, Vol. 44, No. 7
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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