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Antimicrobial Agents and Chemotherapy, July 2000, p. 1995-1996, Vol. 44, No. 7
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Susceptibilities of Yersinia pestis Strains to 12 Antimicrobial Agents

Jane D. Wong, Jason R. Barash, Rebecca F. Sandfort, and J. Michael Janda*

Microbial Diseases Laboratory, Division of Communicable Disease Control, California Department of Health Services, Berkeley, California 94704-1011

Received 14 December 1999/Returned for modification 19 March 2000/Accepted 27 April 2000

Ninety-two strains of Yersinia pestis recovered over a 21-year period were evaluated for susceptibility to traditional and newer antimicrobial agents. In vitro resistance was noted only against rifampin and imipenem (~20% of strains). The most active compounds (MIC at which 90% of the isolates tested are inhibited) against Y. pestis were cefixime, ceftriaxone, trimethoprim-sulfamethoxazole, and trovafloxacin.

* Corresponding author. Mailing address: Microbial Diseases Laboratory, 2151 Berkeley Way, Berkeley, CA 94704-1011. Phone: (510) 540-2242. Fax: (510) 540-2374. E-mail: jjanda{at}dhs.ca.gov.

Antimicrobial Agents and Chemotherapy, July 2000, p. 1995-1996, Vol. 44, No. 7
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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