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Antimicrobial Agents and Chemotherapy, July 2000, p. 2004-2006, Vol. 44, No. 7
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Combination Antifungal Therapy in Treatment of Murine Pulmonary Mucormycosis: Roles of Quinolones and Azolesdagger

Alan M. Sugar* and Xiu-Ping Liu

Evans Memorial Department of Clinical Research and Department of Medicine, Boston Medical Center, Boston, Massachusetts 02118

Received 3 January 2000/Returned for modification 13 March 2000/Accepted 25 April 2000

Amphotericin B is the only recognized antifungal used in the treatment of mucormycosis. In this study, we evaluated various combinations of amphotericin B, fluconazole, and trovafloxacin or ciprofloxacin in the treatment of murine pulmonary mucormycosis. The combination of fluconazole and a quinolone has a marked effect on the outcome of murine pulmonary mucormycosis. Even though we did not optimize therapy with the drugs, these experiments suggest that azoles, especially fluconazole, in combination with either trovafloxacin or ciprofloxacin were effective in the treatment of this aggressive mycosis in the mouse model.

* Corresponding author. Mailing address: Boston Medical Center, EBRC, Room 627, 650 Albany St., Boston, MA 02118. Phone: (617) 638-7905. Fax: (617) 638-8070. E-mail: asugar{at}medicine.bu.edu.

dagger Publication no. 017 from the Collaborative Medical Mycology Research Program (Section of Infectious Diseases, Department of Medicine, Boston Medical Center and Pfizer, Roerig Division).

Antimicrobial Agents and Chemotherapy, July 2000, p. 2004-2006, Vol. 44, No. 7
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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