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Antimicrobial Agents and Chemotherapy, August 2000, p. 2166-2169, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Antimicrobial Resistance and Spread of Class 1 Integrons among Salmonella Serotypes

Beatriz Guerra,1 Sara Soto,1 Santiago Cal,2 and M. Carmen Mendoza1,*

Área de Microbiología, Departamento de Biología Funcional,1 and Departamento de Bioquímica y Biología Molecular,2 Universidad de Oviedo, Principado de Asturias, Spain

Received 18 February 2000/Returned for modification 28 March 2000/Accepted 24 May 2000

The resistance profiles, for 15 antimicrobial agents, of 333 Salmonella strains representing the most frequent nontyphoidal serotypes, isolated between 1989 and 1998 in a Spanish region, and 9 reference strains were analyzed. All strains were susceptible to amikacin, ceftazidime, ciprofloxacin, and imipenem, and 31% were susceptible to all antimicrobials tested. The most frequent types of resistance were to sulfadiazine, tetracycline, streptomycin, spectinomycin, ampicillin, and chloramphenicol (ranging from 46 to 22%); 13% were resistant to these six drugs. This multidrug resistance pattern was found alone or together with other resistance types within serotypes Typhimurium (45%), Panama (23%), and Virchow (4%). Each isolate was also screened for the presence of class 1 integrons and selected resistance genes therein; seven variable regions which carried one (aadA1a, aadA2, or pse-1) or two (dfrA14-aadA1a, dfrA1-aadA1a, oxa1-aadA1a, or sat1-aadA1a) resistance genes were found in integrons.

* Corresponding author. Mailing address: Área de Microbiología, Dpto. Biología Funcional, Facultad Medicina, Universidad de Oviedo, C/ Julián Clavería s/n, 33006 Oviedo (Asturias), Spain. Phone: 34-985-103560. Fax: 34-985-103148. E-mail: camf{at}sauron.quimica.uniovi.es.

Antimicrobial Agents and Chemotherapy, August 2000, p. 2166-2169, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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