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Antimicrobial Agents and Chemotherapy, August 2000, p. 2173-2175, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Indinavir Population Pharmacokinetics in Plasma and Cerebrospinal Fluid

Scott L. Letendre,1,* Edmund V. Capparelli,2 Ronald J. Ellis,1 J. Allen McCutchan,1 and The HIV NEUROBEHAVIORAL RESEARCH CENTER GROUP

HIV Neurobehavioral Research Center1 and Pediatric Pharmacology Research Unit,2 University of California, San Diego, California

Received 10 August 1999/Returned for modification 16 December 1999/Accepted 25 April 2000

Plasma and cerebrospinal fluid (CSF) indinavir concentrations were measured by high-performance liquid chromatography. The median concentration in plasma exceeded that in CSF 10-fold. The modeled CSF curve was flat at 155 nM, and the estimated ratio of the areas under the CSF and plasma concentration-time curves was 6%. We conclude that CSF indinavir concentrations are lower than levels in plasma but exceed the clinical 95% inhibitory concentration range.

* Corresponding author. Mailing address: HIV Neurobehavioral Research Center, University of California, San Diego, 150 W. Washington St., San Diego, CA 92103. Phone: (619) 543-4730. Fax: (619) 543-1235. E-mail: sletendre{at}ucsd.edu.

Antimicrobial Agents and Chemotherapy, August 2000, p. 2173-2175, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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