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Antimicrobial Agents and Chemotherapy, August 2000, p. 2187-2189, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Impact of n-6 Polyunsaturated Fatty Acids on Growth of Multidrug-Resistant Pseudomonas aeruginosa: Interactions with Amikacin and Ceftazidime

E. J. Giamarellos-Bourboulis,1 P. Grecka,2 A. Dionyssiou-Asteriou,3 and H. Giamarellou2,*

1st Department of Propedeutic Medicine,1 4th Department of Internal Medicine,2 and Department of Biological Chemistry,3 Athens Medical School, Athens, Greece

Received 9 April 1999/Returned for modification 29 November 1999/Accepted 1 May 2000

Twenty-six multidrug-resistant Pseudomonas aeruginosa isolates were exposed over time to 300 µg of gamma-linolenic acid or arachidonic acid per ml or to the combination of both acids at 150 µg/ml each with ceftazidime and amikacin with or without albumin to observe the in vitro interactions of the antibiotics. Antibiotics and albumin were applied at their levels found in serum. Synergy between acids and antibiotics was found against 13 isolates, and it was expressed after 5 h of growth in the presence of albumin. The results indicate that further application in experimental infection models is merited.

* Corresponding author. Mailing address: 4th Department of Internal Medicine, Sismanoglion General Hospital, 151 26 Maroussi Attikis, Greece. Phone: (301) 80 39 542. Fax: (301) 80 39 543.

Antimicrobial Agents and Chemotherapy, August 2000, p. 2187-2189, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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