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Antimicrobial Agents and Chemotherapy, August 2000, p. 2201-2204, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Biochemical-Genetic Characterization and Distribution of OXA-22, a Chromosomal and Inducible Class D beta -Lactamase from Ralstonia (Pseudomonas) pickettii

Patrice Nordmann,* Laurent Poirel, Maryline Kubina, Anne Casetta, and Thierry Naas

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre, France

Received 1 December 1999/Returned for modification 28 March 2000/Accepted 19 May 2000

From genomic DNA of Ralstonia pickettii isolate PIC-1, a beta -lactamase gene was cloned that encodes the oxacillinase OXA-22. It differs from known oxacillinases, being most closely related to OXA-9 (38% amino acid identity). The hydrolytic spectrum of OXA-22 is limited mostly to benzylpenicillin, cloxacillin, and restricted-spectrum cephalosporins. OXA-22-like genes were identified as single chromosomal copies in five other R. pickettii clinical isolates. The expression of OXA-22-like beta -lactamases was inducible in R. pickettii.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France. Phone: 33 1 45 21 36 32. Fax: 33 1 45 21 63 40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, August 2000, p. 2201-2204, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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