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Antimicrobial Agents and Chemotherapy, August 2000, p. 2222-2224, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

In Vitro Activities of MK-826 (L-749,345) against 363 Strains of Anaerobic Bacteria

Hannah M. Wexler,1,2,* Denise Molitoris,1 and Sydney M. Finegold1,2,3,4

Medical3 and Research1 Services, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California 90073, and Departments of Medicine2 and Microbiology and Immunology,4 UCLA School of Medicine, Los Angeles, California 90024

Received 31 January 2000/Returned for modification 22 February 2000/Accepted 2 May 2000

The activity of MK-826 was compared to the activities of cefoxitin, ceftriaxone, imipenem, and meropenem against 363 gram-negative and gram-positive anaerobes by using NCCLS procedures. At least 98% of the strains were susceptible to the carbapenems. All strains of Clostridium perfringens, Fusobacterium nucleatum, Peptostreptococcus, and Sutterella wadsworthensis were susceptible to all agents tested.

* Corresponding author. Mailing address: Microbial Diseases Research Laboratory, Bldg. 304, Room E3-224, VAGLAHS 691/151J, Los Angeles, CA 90073. Phone: (310) 268-3404. Fax: (310) 268-4458. E-mail: hwexler{at}ucla.edu.

Antimicrobial Agents and Chemotherapy, August 2000, p. 2222-2224, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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