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Antimicrobial Agents and Chemotherapy, September 2000, p. 2569-2571, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Fluconazole Penetration into the Pancreas

Shailesh Shrikhande,1 Helmut Friess,1,* Claudia Issenegger,1 Marcus E. Martignoni,1 Huang Yong,1 Beat Gloor,1 Rodney Yeates,2 Jörg Kleeff,1 and Markus W. Büchler1

Department of Visceral and Transplantation Surgery, University of Bern, Bern, Switzerland,1 and Pfizer Mack Research Laboratory, Illertissen, Germany2

Received 18 January 2000/Returned for modification 17 March 2000/Accepted 24 May 2000

Because of antibiotic prophylaxis for necrotizing pancreatitis, the frequency of fungal superinfection in patients with pancreatic necrosis is increasing. In this study we analyzed the penetration of fluconazole into the human pancreas and in experimental acute pancreatitis. In human pancreatic tissues, the mean fluconazole concentration was 8.19 ± 3.38 µg/g (96% of the corresponding concentration in serum). In experimental edematous and necrotizing pancreatitis, 88 and 91% of the serum fluconazole concentration was found in the pancreas. These data show that fluconazole penetration into the pancreas is sufficient to prevent and/or treat fungal contamination in patients with pancreatic necrosis.

* Corresponding author. Mailing address: Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, CH-3010 Bern, Switzerland. Phone: 41 31 632 9578. Fax: 41 31 632 9732. E-mail: helmut.friess{at}insel.ch.

Antimicrobial Agents and Chemotherapy, September 2000, p. 2569-2571, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Cuschieri, A. (2002). Pancreatic Necrosis: Pathogenesis and Endoscopic Management. SURG INNOV 9: 54-63 [Abstract]  


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