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Antimicrobial Agents and Chemotherapy, January 2001, p. 324-326, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.324-326.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Nitrofurantoin Is Active against Vancomycin-Resistant Enterococci

George G. Zhanel,* Daryl J. Hoban, and James A. Karlowsky

Departments of Clinical Microbiology and Medicine, Health Sciences Centre and Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada

Received 2 December 1999/Returned for modification 28 July 2000/Accepted 17 October 2000

The activity of nitrofurantoin was tested against 300 isolates of Enterococcus faecium, Enterococcus faecalis, and Enterococcus gallinarum. No isolates tested were resistant to nitrofurantoin (MIC, >= 128 µg/ml), including vancomycin-resistant E. faecium isolates with vanA- and vanB-positive genotypes and vancomycin-resistant E. gallinarum isolates. We conclude that nitrofurantoin may provide effective treatment of urinary tract infections caused by vancomycin-resistant enterococci.

* Corresponding author. Mailing address: Department of Clinical Microbiology, Health Sciences Centre, MS673, 820 Sherbrook St., Winnipeg, Manitoba R3A 1R9, Canada. Phone: (204) 787-4902. Fax: (204) 787-4699. E-mail: ggzhanel{at}pcs.mb.ca.

Antimicrobial Agents and Chemotherapy, January 2001, p. 324-326, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.324-326.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Zhanel, G. G., Laing, N. M., Nichol, K. A., Palatnick, L. P., Noreddin, A., Hisanaga, T., Johnson, J. L., the NAVRESS Group, , Hoban, D. J. (2003). Antibiotic activity against urinary tract infection (UTI) isolates of vancomycin-resistant enterococci (VRE): results from the 2002 North American Vancomycin Resistant Enterococci Susceptibility Study (NAVRESS). J Antimicrob Chemother 52: 382-388 [Abstract] [Full Text]  


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