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Antimicrobial Agents and Chemotherapy, January 2001, p. 339-341, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.339-341.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Prevalence and Mechanisms of Macrolide Resistance in Streptococcus pyogenes in Santiago, Chile

E. L. Palavecino,1,dagger I. Riedel,1 X. Berrios,1 S. Bajaksouzian,2 D. Johnson,3 E. Kaplan,3 and M. R. Jacobs2,*

Laboratory Services and Department of Public Health, Universidad Catolica, Santiago, Chile1; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 554553; and Department of Pathology, Case Western Reserve University, and University Hospitals of Cleveland, Cleveland, Ohio 441062

Received 7 March 2000/Returned for modification 24 July 2000/Accepted 3 October 2000

Thirty-two macrolide-resistant Streptococcus pyogenes isolates were found among 594 clinical isolates collected from 1990 to 1998 in Santiago, Chile, for an overall prevalence of 7.2%. Among the 32 resistant isolates, 28 (87.5%) presented the M phenotype and 4 (12.5%) presented the MLSB phenotype. Serotyping and pulsed-field gel electrophoresis analysis showed genetic diversity among the resistant isolates.


* Corresponding author. Mailing address: Department of Pathology, University Hospitals of Cleveland, 11100 Euclid Ave., Cleveland, OH 44106. Phone: (216) 844-3484. Fax: (216) 844-5601. E-mail: mrj6{at}po.cwru.edu.

dagger Present address: Department of Pathology, University Hospitals of Cleveland, Cleveland, OH 44106.


Antimicrobial Agents and Chemotherapy, January 2001, p. 339-341, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.339-341.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.



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