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Antimicrobial Agents and Chemotherapy, January 2001, p. 349-352, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.349-352.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Clinical Isolate of Vancomycin-Heterointermediate Staphylococcus aureus Susceptible to Methicillin and In Vitro Selection of a Vancomycin-Resistant Derivative

Sophie Bobin-Dubreux,1 Marie-Elisabeth Reverdy,1 Chantal Nervi,1 Martine Rougier,1 Anne Bolmström,2 François Vandenesch,1 and Jerome Etienne1,*

Laboratoire de Microbiologie, EA 1655, Hôpital Edouard Herriot, 69437 Lyon cedex 03, France,1 and AB BIODISK, S-169 56 Solna, Sweden2

Received 28 June 2000/Returned for modification 11 September 2000/Accepted 17 October 2000

A Staphylococcus aureus strain with low-level heteroresistance to vancomycin (designated MER) but susceptible to methicillin was isolated from an outpatient with conjunctivitis who did not receive any glycopeptide antibiotics. Incubation of the parent strain, MER, with increasing concentrations of vancomycin led to rapid selection of a stable progeny homogeneously resistant to vancomycin. Electron micrographs of strain MER showed enhanced cell wall thickness and abnormal septations typically seen with methicillin-resistant S. aureus having intermediate susceptibility to vancomycin.

* Corresponding author. Mailing address: Laboratoire de Microbiologie, EA 1655, Hôpital Edouard Herriot, 5 Place d'Arsonval. 69437 Lyon cedex 03, France. Phone: 33 (0) 472 11 05 94. Fax: 33 (0) 472 11 07 64. E-mail: jetienne{at}univ-lyon1.fr.

Antimicrobial Agents and Chemotherapy, January 2001, p. 349-352, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.349-352.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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