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Antimicrobial Agents and Chemotherapy, January 2001, p. 363-366, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.363-366.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Therapeutic Efficacy of Poly(DL-Lactide-Co-Glycolide)-Encapsulated Antitubercular Drugs against Mycobacterium tuberculosis Infection Induced in Mice

Manisha Dutt and G. K. Khuller*

Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India

Received 28 June 2000/Returned for modification 26 August 2000/Accepted 25 October 2000

Poly(DL-lactide-co-glycolide) (PLG) microparticles were developed as carriers for isoniazid and rifampin in order to improve compliance of tuberculous chemotherapy. Antitubercular drugs encapsulated in PLG polymers and injected in a single dose subcutaneously resulted in a sustained release (up to 6 weeks) of drugs in various organs of mice. Further, Mycobacterium tuberculosis H37Rv-infected animals given a single shot of chemotherapy in PLG microparticles exhibited a better or equivalent clearance of CFU in various organs compared to those given a daily administration of free drugs.

* Corresponding author. Mailing address: Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India. Phone: 747 585, ext. 282, 274. Fax: 744 401, 745 078. E-mail: medinst{at}pgi.chd.nic.in.

Antimicrobial Agents and Chemotherapy, January 2001, p. 363-366, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.363-366.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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  • Pandey, R., Sharma, A., Zahoor, A., Sharma, S., Khuller, G. K., Prasad, B. (2003). Poly (DL-lactide-co-glycolide) nanoparticle-based inhalable sustained drug delivery system for experimental tuberculosis. J Antimicrob Chemother 52: 981-986 [Abstract] [Full Text]  
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