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Antimicrobial Agents and Chemotherapy, October 2001, p. 2928-2930, Vol. 45, No. 10
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.10.2928-2930.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Effects of New Quinolones on Transepithelial Electrical Potential Difference of Tracheal Mucosa In Vivo

Soichiro Kanoh, Jun Tamaoki, Mitsuko Kondo, Yuko Nagano, and Atsushi Nagai^*

First Department of Medicine, Tokyo Women's Medical University School of Medicine, Tokyo 162-8666, Japan

Received 5 October 2000/Returned for modification 26 April 2001/Accepted 16 July 2001

Superfusion of canine tracheal mucosa with 100 µg each of grepafloxacin and ciprofloxacin per ml reduced the electrical transepithelial potential difference in vivo by more than 50%. This effect was dose dependent, specific for new quinolones, and inhibited by Cl channel blockers, indicating that new quinolones attenuate Cl secretion across the airway epithelium.

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^* Corresponding author. Mailing address: First Department of Medicine, Tokyo Women's Medical University School of Medicine, 8-1 Kawada-Cho, Shinjuku, Tokyo 162-8666, Japan. Phone: 81-3-3353-8111. Fax: 81-3-5379-5457. E-mail: a-nagai{at}tkd.att.ne.jp.

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Antimicrobial Agents and Chemotherapy, October 2001, p. 2928-2930, Vol. 45, No. 10
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.10.2928-2930.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.