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Antimicrobial Agents and Chemotherapy, October 2001, p. 2936-2938, Vol. 45, No. 10
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.10.2936-2938.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Comparison of Once-Daily versus Twice-Daily Administration of Cefdinir against Typical Bacterial Respiratory Tract Pathogens

Gigi H. Ross,1,2 Laurie Baeker Hovde,1 Khalid H. Ibrahim,1,2 Yasir H. Ibrahim,1,2 and John C. Rotschafer1,2,*

College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455,1 and Department of Clinical Pharmacy, Regions Hospital, St. Paul, Minnesota 551012

Received 17 April 2000/Returned for modification 11 October 2000/Accepted 17 July 2001

In an in vitro pharmacodynamic model, a twice-daily cefdinir dosing regimen was more effective than a once-daily regimen against common bacterial respiratory pathogens in producing 3-log10 killing and preventing the occurrence of regrowth at 24 h. Twice-daily administration is likely the more appropriate cefdinir dosing strategy for the treatment of community-acquired pneumonia.

* Corresponding author. Mailing address: Department of Clinical Pharmacy, Regions Hospital, 640 Jackson St., St. Paul, MN 55101. Phone: (651) 254-3896. Fax: (651) 254-9539. E-mail: rotsc001{at}tc.umn.edu.

Antimicrobial Agents and Chemotherapy, October 2001, p. 2936-2938, Vol. 45, No. 10
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.10.2936-2938.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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  • Paradise, J. L. (2002). A 15-Month-Old Child With Recurrent Otitis Media. JAMA 288: 2589-2598 [Full Text]  


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