This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Raad, I.
Right arrow Articles by Bodey, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Raad, I.
Right arrow Articles by Bodey, G.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, November 2001, p. 3202-3204, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3202-3204.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Treatment of Vancomycin-Resistant Enterococcal Infections in the Immunocompromised Host: Quinupristin-Dalfopristin in Combination with Minocycline

Issam Raad,* Ray Hachem, Hend Hanna, Essam Girgawy, Kenneth Rolston, Estella Whimbey, Rola Husni, and Gerald Bodey

Section of Infectious Diseases, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4095

Received 5 June 2000/Returned for modification 27 January 2001/Accepted 30 July 2001

Between February 1994 and November 1998, 56 oncology patients infected with vancomycin-resistant enterococci (VRE) were treated with quinopristin-dalfopristin (Q-D) plus minocycline (MIN). Infections included bacteremia, urinary tract infection, pneumonia, and wound infection. The response rate was 68%, and the most frequent adverse event was arthralgia or myalgia (36%). Q-D-MIN is effective for VRE infection in cancer patients but is associated with a substantial frequency of arthralgia or myalgia.

* Corresponding author. Mailing address: The University of Texas M. D. Anderson Cancer Center, Department of Infectious Diseases, Infection Control and Employee Health (Box 402), 1515 Holcombe Blvd., Houston, TX 77030-4095. Phone: (713) 792-7943. Fax: (713) 792-8233. E-mail: iraad{at}mdanderson.org.

Antimicrobial Agents and Chemotherapy, November 2001, p. 3202-3204, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3202-3204.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Raad, I. I., Hanna, H. A., Boktour, M., Chaiban, G., Hachem, R. Y., Dvorak, T., Lewis, R., Murray, B. E. (2005). Vancomycin-Resistant Enterococcus faecium: Catheter Colonization, esp Gene, and Decreased Susceptibility to Antibiotics in Biofilm. Antimicrob. Agents Chemother. 49: 5046-5050 [Abstract] [Full Text]  
  • Raad, I. I., Hanna, H. A., Hachem, R. Y., Dvorak, T., Arbuckle, R. B., Chaiban, G., Rice, L. B. (2004). Clinical-Use-Associated Decrease in Susceptibility of Vancomycin-Resistant Enterococcus faecium to Linezolid: a Comparison with Quinupristin-Dalfopristin. Antimicrob. Agents Chemother. 48: 3583-3585 [Abstract] [Full Text]  
  • Raad, I., Hachem, R., Hanna, H. (2004). Relationship between myalgias/arthralgias occurring in patients receiving quinupristin/dalfopristin and biliary dysfunction. J Antimicrob Chemother 53: 1105-1108 [Abstract] [Full Text]  
  • Raad, I., Hachem, R., Hanna, H., Afif, C., Escalante, C., Kantarjian, H., Rolston, K. (2004). Prospective, randomized study comparing quinupristin-dalfopristin with linezolid in the treatment of vancomycin-resistant Enterococcus faecium infections. J Antimicrob Chemother 53: 646-649 [Abstract] [Full Text]  
  • Smith, P. F., Birmingham, M. C., Noskin, G. A., Meagher, A. K., Forrest, A., Rayner, C. R., Schentag, J. J. (2003). Safety, efficacy and pharmacokinetics of linezolid for treatment of resistant Gram-positive infections in cancer patients with neutropenia. Ann Oncol 14: 795-801 [Abstract] [Full Text]  
  • (2001). Quinupristin-Dalfopristin Plus Minocycline for VRE Infections in Immunocompromised Patients. JWatch Infect. Diseases 2001: 7-7 [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»