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Antimicrobial Agents and Chemotherapy, November 2001, p. 3209-3212, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3209-3212.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro Killing of Candida albicans by Fatty Acids and Monoglycerides

Gudmundur Bergsson,1,* Jóhann Arnfinnsson,2 Ólafur Steingrímsson,3 and Halldor Thormar1

Institute of Biology, University of Iceland,1 Department of Anatomy, University of Iceland Medical School,2 and Department of Microbiology, National University Hospital,3 Reykjavik, Iceland

Received 11 December 2000/Returned for modification 3 January 2001/Accepted 9 August 2001

The susceptibility of Candida albicans to several fatty acids and their 1-monoglycerides was tested with a short inactivation time, and ultrathin sections were studied by transmission electron microscopy (TEM) after treatment with capric acid. The results show that capric acid, a 10-carbon saturated fatty acid, causes the fastest and most effective killing of all three strains of C. albicans tested, leaving the cytoplasm disorganized and shrunken because of a disrupted or disintegrated plasma membrane. Lauric acid, a 12-carbon saturated fatty acid, was the most active at lower concentrations and after a longer incubation time.

* Corresponding author. Mailing address: Institute of Biology, University of Iceland, Grensasvegur 12, 108 Reykjavik, Iceland. Phone: 354-525 4602. Fax: 354-525 4069. E-mail: gudmunb{at}hi.is.

Antimicrobial Agents and Chemotherapy, November 2001, p. 3209-3212, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3209-3212.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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