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Antimicrobial Agents and Chemotherapy, November 2001, p. 3220-3222, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3220-3222.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Synergistic Activities of Gatifloxacin in Combination with Other Antimicrobial Agents against Pseudomonas aeruginosa and Related Species

Elizabeth Gradelski, Lourdes Valera, Daniel Bonner, and Joan Fung-Tomc*

Department of Microbiology, Bristol-Myers Squibb Company, Wallingford, Connecticut 06492

Received 12 March 2001/Returned for modification 9 June 2001/Accepted 3 August 2001

Drug combinations have been used to treat serious infections caused by Pseudomonas, Burkholderia, Stenotrophomonas, and Acinetobacter. In this study, the combined drug effects of gatifloxacin (GAT) and nonquinolones were determined by time-kill analysis at clinically achievable drug concentrations. Synergy (>= 2 log10-enhanced killing at 24 h) was observed with GAT plus amikacin or a beta -lactam against 50 to 75% of strains, including strains nonsusceptible to one or both drugs.

* Corresponding author. Mailing address: Department of Microbiology-104, Bristol-Myers Squibb Company, 5 Research Pkwy., Wallingford, CT 06492. Phone: (203) 677-6370. Fax: (203) 677-6771. E-mail: fungtomj{at}bms.com.

Antimicrobial Agents and Chemotherapy, November 2001, p. 3220-3222, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3220-3222.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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