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Antimicrobial Agents and Chemotherapy, November 2001, p. 3242-3245, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3242-3245.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Activities of a New Fluoroketolide, HMR 3787, and Its (Des)-Fluor Derivative RU 64399 Compared to Those of Telithromycin, Erythromycin A, Azithromycin, Clarithromycin, and Clindamycin against Macrolide-Susceptible or -Resistant Streptococcus pneumoniae and S. pyogenes

Kensuke Nagai,1 Todd A. Davies,1 Lois M. Ednie,1 Andre Bryskier,2 Elizabeth Palavecino,3 Michael R. Jacobs,3 and Peter C. Appelbaum1,*

Hershey Medical Center, Hershey, Pennsylvania 170331; Hoechst Marion Roussel Aventis Anti-infectives, Romainville, France2; and Case Western Reserve University, Cleveland, Ohio 441063

Received 1 March 2001/Returned for modification 1 June 2001/Accepted 30 July 2001

Activities of HMR 3787 and RU 64399 were compared to those of three macrolides, telithromycin, and clindamycin against 175 Streptococcus pneumoniae isolates and 121 Streptococcus pyogenes isolates. HMR3787 and telithromycin were the most active compounds tested against pneumococci. Telithromycin and RU 64399 were equally active against macrolide-susceptible (MICs, 0.008 to 0.06 µg/ml) and -resistant S. pyogenes isolates, but HMR 3787 had lower MICs for ermB strains.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.

Antimicrobial Agents and Chemotherapy, November 2001, p. 3242-3245, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3242-3245.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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