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Antimicrobial Agents and Chemotherapy, November 2001, p. 3267-3269, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3267-3269.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Aminoglycoside-Streptothricin Resistance Gene Cluster aadE-sat4-aphA-3 Disseminated among Multiresistant Isolates of Enterococcus faecium

Guido Werner,* Bianca Hildebrandt, and Wolfgang Witte

Wernigerode Branch, Robert Koch-Institute, 38855 Wernigerode, Germany

Received 7 February 2001/Returned for modification 5 April 2001/Accepted 31 July 2001

Seventy-two Enterococcus faecium isolates of different origins highly resistant to nourseothricin and streptomycin were studied. Sequencing of a genomic fragment from two isolates identified a gene cluster, aadE-sat4-aphA-3, which has been isolated recently in staphylococci and Campylobacter coli. Patterns of digested PCR products of aadE-sat4-aphA-3 were identical for all isolates.

* Corresponding author. Mailing address: Robert Koch-Institut, Wernigerode Branch, Burgstr. 37, 38855 Wernigerode, Germany. Phone: 49 3943 679 210. Fax: 49 3943 679 207. E-mail: wernerg{at}rki.de.

Antimicrobial Agents and Chemotherapy, November 2001, p. 3267-3269, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3267-3269.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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