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Antimicrobial Agents and Chemotherapy, November 2001, p. 3270-3272, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3270-3272.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro and In Vivo Activities of Sitafloxacin against Chlamydia spp.

Naoyuki Miyashita,* Yoshihito Niki, and Toshiharu Matsushima

Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 701-0192, Japan

Received 13 July 2000/Returned for modification 6 December 2000/Accepted 23 July 2001

The in vitro and in vivo antichlamydial activity of sitafloxacin was investigated. The MICs and minimal chlamydiacidal concentrations of sitafloxacin for various species of chlamydia ranged from 0.031 to 0.125 µg/ml. Sitafloxacin had an excellent therapeutic effect on experimental Chlamydia psittaci pneumonia and was more potent than tosufloxacin, ofloxacin, and ciproflxacin, although slightly less potent than sparfloxacin.

* Corresponding author. Mailing address: Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 701-0192, Japan. Phone: 81-86-462-1111. Fax: 81-86-463-6510. E-mail: nao{at}med.kawasaki-m.ac.jp.

Antimicrobial Agents and Chemotherapy, November 2001, p. 3270-3272, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3270-3272.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Miyashita, N., Fukano, H., Yoshida, K., Niki, Y., Matsushima, T. (2003). Chlamydia pneumoniae infection in adult patients with persistent cough. J Med Microbiol 52: 265-269 [Abstract] [Full Text]  


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