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Antimicrobial Agents and Chemotherapy, November 2001, p. 3273-3275, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3273-3275.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Staphylococcus aureus Mutants Selected by BMS-284756

L. F. Discotto,* L. E. Lawrence, K. L. Denbleyker, and J. F. Barrett

Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut

Received 23 April 2001/Returned for modification 27 June 2001/Accepted 27 August 2001

BMS-284756, a novel des-fluoro(6)-quinolone, was used to select for in vitro mutants of Staphylococcus aureus ISP794. Step mutants were obtained, and the quinolone resistance-determining regions of four target genes, gyrA, gyrB, grlA, and grlB, were sequenced. The data suggest that DNA gyrase is the primary target for BMS-284756 in S. aureus.

* Corresponding author. Mailing address: Bristol-Myers Squibb Pharmaceutical Research Institute, Infectious Diseases, Department of Microbiology, 5 Research Pkwy., Wallingford, CT 06492. Phone: (203) 677-6552. Fax: (203) 677-6771. E-mail: Linda.Discotto{at}bms.com.

Antimicrobial Agents and Chemotherapy, November 2001, p. 3273-3275, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3273-3275.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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