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 Previous Article

Antimicrobial Agents and Chemotherapy, November 2001, p. 3276-3278, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3276-3278.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro Susceptibility of Coxiella burnetii to Linezolid in Comparison with Its Susceptibilities to Quinolones, Doxycycline, and Clarithromycin

Achilleas Gikas,* Ioanna Spyridaki, Efstathia Scoulica, Anna Psaroulaki, and Yannis Tselentis

Clinical Bacteriology, Parasitology, Zoonoses, and Geographical Medicine, Collaborating Center of WHO, University of Heraklion, 1352/71110 Crete, Greece

Received 13 February 2001/Returned for modification 5 June 2001/Accepted 6 August 2001

The in vitro susceptibility to linezolid shown by nine Greek isolates of Coxiella burnetii derived from patients with acute Q fever was investigated. MICs of linezolid were compared with those of pefloxacin, ciprofloxacin, ofloxacin, trovafloxacin, doxycycline, and clarithromycin using the shell vial assay. MICs of linezolid and clarithromycin ranged from 2 to 4 µg/ml; those of doxycycline, trovafloxacin, and ofloxacin ranged from 1 to 2 µg/ml; those of pefloxacin ranged from 1 to 4 µg/ml; and those of ciprofloxacin ranged from 4 to 8 µg/ml. Linezolid was effective in controlling intracellular parasites in cultures of Vero cells infected by C. burnetii. No bactericidal activity by linezolid was obtained against C. burnetii at 8 µg/ml.

* Corresponding author. Mailing address: University Hospital of Heraklion, 1352-Heraklion, Crete, Greece. Phone: 30 81 392 360. Fax: 30 81 392 847. E-mail: gikas{at}med.uoc.gr.

Antimicrobial Agents and Chemotherapy, November 2001, p. 3276-3278, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3276-3278.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

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  • MOROVIC, M. (2005). Q FEVER PNEUMONIA: ARE CLARITHROMYCIN AND MOXIFLOXACIN ALTERNATIVE TREATMENTS ONLY?. Am J Trop Med Hyg 73: 947-948 [Abstract] [Full Text]  
  • Rolain, J.-M., Boulos, A., Mallet, M.-N., Raoult, D. (2005). Correlation between Ratio of Serum Doxycycline Concentration to MIC and Rapid Decline of Antibody Levels during Treatment of Q Fever Endocarditis. Antimicrob. Agents Chemother. 49: 2673-2676 [Abstract] [Full Text]  


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