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Antimicrobial Agents and Chemotherapy, December 2001, p. 3433-3436, Vol. 45, No. 12
California Institute for Medical Research and
Department of Medicine, Division of Infectious Diseases, Santa Clara
Valley Medical Center, San Jose, California 95128, and Department of
Medicine, Division of Infectious Diseases and Geographic Medicine,
Stanford University, Stanford, California 94305
Received 22 December 2000/Returned for modification 18 January
2001/Accepted 12 September 2001
A model of orogastric candidosis in SCID mice, which mimics disease
seen in AIDS patients, was used to evaluate ravuconazole in comparison
with fluconazole for treatment. Mice were infected orally with
Candida albicans and received either no treatment or
oral treatment once daily for 12 days with 1, 5, or 25 mg of ravuconazole per kg of body weight per day, 5 or 25 mg of fluconazole per kg per day, or diluent (10% dimethyl sulfoxide in 0.5%
carboxymethyl cellulose). The numbers of C. albicans CFU
in the esophagus, stomach, small intestine, and cecum on day 25 in mice
given no treatment and diluent were equivalent. Both doses of
fluconazole significantly reduced numbers of CFU in all four tissues
but were equivalent to each other. Ravuconazole showed dose-responsive
improvement of clearance of CFU. Ravuconazole at 25 mg/kg was superior
in reduction of numbers of CFU in all tissues to controls or 25 mg of
fluconazole per kg and to other regimens in at least three tissues.
Fluconazole at 25 mg/kg cured no infection in any tissue, whereas 25 mg
of ravuconazole/kg cleared infection in all tissues from 50% of mice.
Ravuconazole has good efficacy and the potential to cure mucosal
candidosis in the absence of a functional immune response.
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.12.3433-3436.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Efficacy of Ravuconazole in Treatment of Mucosal
Candidosis in SCID Mice
*
Corresponding author. Mailing address: Division of
Infectious Diseases, Dept. of Medicine, Santa Clara Valley Medical
Center, 751 South Bascom Ave. San Jose, CA 95128-2699. Phone: (408)
998-4557. Fax: (408) 998-2723. E-mail: clemons{at}cimr.org.
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