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Antimicrobial Agents and Chemotherapy, December 2001, p. 3603-3606, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3603-3606.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Outbreak of Cefozopran (Penicillin, Oral Cephems, and Aztreonam)-Resistant Neisseria gonorrhoeae in Japan

Tetsuro Muratani,1,* Soichiro Akasaka,1 Tomoko Kobayashi,2 Yoji Yamada,1 Hisato Inatomi,1 Koichi Takahashi,1 and Tetsuro Matsumoto1

Department of Urology, School of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu,1 and Kyurin Co., 27-25, Morishita, Yahatanishi-ku, Kitakyushu,2 Japan

Received 27 November 2000/Returned for modification 1 June 2001/Accepted 30 August 2001

We have previously reported that the Neisseria gonorrhoeae isolates from clinical failure cases treated with cefdinir and aztreonam, beta -lactams exhibited high MICs. These resistant isolates were clearly separated from the isolates exhibiting a low level of resistance to beta -lactams as shown by the MIC distribution of cefozopran. Restriction fragment length polymorphism DNA typing revealed that the outbreak of cefozopran-resistant isolates in Kitakyushu, Japan, occurred as a result of clonal spread.

* Corresponding author. Mailing address: Department of Urology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. Phone: 81 93 691 7446. Fax: 81 93 603 8724. E-mail: muratani{at}med.uoeh-u.ac.jp.

Antimicrobial Agents and Chemotherapy, December 2001, p. 3603-3606, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3603-3606.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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