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Antimicrobial Agents and Chemotherapy, December 2001, p. 3651-3653, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3651-3653.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Evolution of TEM-Related Extended-Spectrum beta -Lactamases in Korea

Hyunjoo Pai,1,2 Hoan-Jong Lee,3 Eun-Hwa Choi,3 Jungmin Kim,4 and George A. Jacoby2,*

Department of Internal Medicine1 and Department of Microbiology,4 College of Medicine, Dankook University, Chonan, and Department of Pediatrics, Seoul National University College of Medicine, Seoul,3 Korea, and Edith Nourse Rogers Memorial Veterans Hospital, Bedford, and Lahey Clinic, Burlington, Massachusetts2

Received 23 February 2001/Returned for modification 23 June 2001/Accepted 21 August 2001

TEM-52, differing from TEM-1 by having the substitutions Glu-104right-arrowLys, Met-182right-arrowThr, and Gly-238right-arrowSer, has previously been described as the most prevalent extended-spectrum beta -lactamase (ESBL) in Korea. In a further survey, we discovered the ESBLs TEM-15, which is like TEM-52 but lacks the substitution at residue 182, and TEM-88, which is like TEM-52 with an additional Gly-196right-arrowAsp substitution. TEM-88 retained the activity of TEM-52 against moxalactam. Otherwise, the kinetic properties of the three ESBLs failed to show an advantage to this evolution.

* Corresponding author. Mailing address: Lahey Clinic, 41 Mall Rd., Burlington, MA 01805. Phone: (781) 744-8608. Fax: (781) 744-1264. E-mail: george.a.jacoby{at}lahey.org.

Antimicrobial Agents and Chemotherapy, December 2001, p. 3651-3653, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3651-3653.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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