This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blondeau, J. M.
Right arrow Articles by Drlica, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blondeau, J. M.
Right arrow Articles by Drlica, K.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, February 2001, p. 433-438, Vol. 45, No. 2
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.2.433-438.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Mutant Prevention Concentrations of Fluoroquinolones for Clinical Isolates of Streptococcus pneumoniae

Joseph M. Blondeau,1,* Xilin Zhao,2 Glen Hansen,1 and Karl Drlica2

Departments of Clinical Microbiology, St. Paul's Hospital (Grey Nuns') and Saskatoon District Health; Department of Pathology, Royal University Hospital; and Department of Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada1; and Public Health Research Institute, New York, New York 100162

Received 30 August 2000/Returned for modification 19 October 2000/Accepted 2 November 2000

The mutant prevention concentration (MPC) represents a threshold above which the selective proliferation of resistant mutants is expected to occur only rarely. A provisional MPC (MPCpr) was defined and measured for five fluoroquinolones with clinical isolates of Streptococcus pneumoniae. Based on their potential for restricting the selection of resistant mutants, the five fluoroquinolones, in descending order, were found to be moxifloxacin > trovafloxacin > gatifloxacin > grepafloxacin > levofloxacin. For several compounds, 90% of about 90 clinical isolates that lacked a known resistance mutation had a value of MPCpr that was close to or below the serum levels that could be attained with a dosing regimen recommended by the manufacturers. Since MPCpr overestimates MPC, these data identify moxifloxacin and gatifloxacin as good candidates for determining whether MPCpr can be used as a guide for choosing and eventually administering fluoroquinolones to significantly reduce the development of resistance.

* Corresponding author. Mailing address: Department of Clinical Microbiology, Royal University Hospital, 103 Hospital Ave., Saskatoon, Saskatchewan S7N 0W8, Canada. Phone: (306) 655-6943. Fax: (306) 655-6947. E-mail: blondeauj{at}sdh.sk.ca.

Antimicrobial Agents and Chemotherapy, February 2001, p. 433-438, Vol. 45, No. 2
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.2.433-438.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Kesteman, A.-S., Ferran, A. A., Perrin-Guyomard, A., Laurentie, M., Sanders, P., Toutain, P.-L., Bousquet-Melou, A. (2009). Influence of Inoculum Size and Marbofloxacin Plasma Exposure on the Amplification of Resistant Subpopulations of Klebsiella pneumoniae in a Rat Lung Infection Model. Antimicrob. Agents Chemother. 53: 4740-4748 [Abstract] [Full Text]  
  • Allou, N., Cambau, E., Massias, L., Chau, F., Fantin, B. (2009). Impact of Low-Level Resistance to Fluoroquinolones Due to qnrA1 and qnrS1 Genes or a gyrA Mutation on Ciprofloxacin Bactericidal Activity in a Murine Model of Escherichia coli Urinary Tract Infection. Antimicrob. Agents Chemother. 53: 4292-4297 [Abstract] [Full Text]  
  • Singh, R., Ledesma, K. R., Chang, K.-T., Hou, J.-G., Prince, R. A., Tam, V. H. (2009). Pharmacodynamics of moxifloxacin against a high inoculum of Escherichia coli in an in vitro infection model. J Antimicrob Chemother 64: 556-562 [Abstract] [Full Text]  
  • Allen, G. P., Hankins, C. D. (2009). Evaluation of the mutant selection window for fluoroquinolones against Neisseria gonorrhoeae. J Antimicrob Chemother 64: 359-363 [Abstract] [Full Text]  
  • Yamamoto, K., Yanagihara, K., Sugahara, K., Imamura, Y., Seki, M., Izumikawa, K., Kakeya, H., Yamamoto, Y., Hirakata, Y., Kamihira, S., Kohno, S. (2009). In Vitro Activity of Garenoxacin against Streptococcus pneumoniae Mutants with Characterized Resistance Mechanisms. Antimicrob. Agents Chemother. 53: 3572-3575 [Abstract] [Full Text]  
  • Ferran, A. A., Kesteman, A.-S., Toutain, P.-L., Bousquet-Melou, A. (2009). Pharmacokinetic/Pharmacodynamic Analysis of the Influence of Inoculum Size on the Selection of Resistance in Escherichia coli by a Quinolone in a Mouse Thigh Bacterial Infection Model. Antimicrob. Agents Chemother. 53: 3384-3390 [Abstract] [Full Text]  
  • Muller-Serieys, C., Saleh Mghir, A., Massias, L., Fantin, B. (2009). Bactericidal Activity of the Combination of Levofloxacin with Rifampin in Experimental Prosthetic Knee Infection in Rabbits Due to Methicillin-Susceptible Staphylococcus aureus. Antimicrob. Agents Chemother. 53: 2145-2148 [Abstract] [Full Text]  
  • Michel, J.-B., Yeh, P. J., Chait, R., Moellering, R. C. Jr., Kishony, R. (2008). Drug interactions modulate the potential for evolution of resistance. Proc. Natl. Acad. Sci. USA 105: 14918-14923 [Abstract] [Full Text]  
  • Zhao, X., Drlica, K. (2008). A unified anti-mutant dosing strategy. J Antimicrob Chemother 62: 434-436 [Abstract] [Full Text]  
  • Cesaro, A., Bettoni, R. R. D., Lascols, C., Merens, A., Soussy, C. J., Cambau, E. (2008). Low selection of topoisomerase mutants from strains of Escherichia coli harbouring plasmid-borne qnr genes. J Antimicrob Chemother 61: 1007-1015 [Abstract] [Full Text]  
  • Oonishi, Y., Mitsuyama, J., Yamaguchi, K. (2007). Effect of GrlA mutation on the development of quinolone resistance in Staphylococcus aureus in an in vitro pharmacokinetic model. J Antimicrob Chemother 60: 1030-1037 [Abstract] [Full Text]  
  • Homma, T., Hori, T., Sugimori, G., Yamano, Y. (2007). Pharmacodynamic Assessment Based on Mutant Prevention Concentrations of Fluoroquinolones To Prevent the Emergence of Resistant Mutants of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 51: 3810-3815 [Abstract] [Full Text]  
  • Ferran, A., Dupouy, V., Toutain, P.-L., Bousquet-Melou, A. (2007). Influence of Inoculum Size on the Selection of Resistant Mutants of Escherichia coli in Relation to Mutant Prevention Concentrations of Marbofloxacin. Antimicrob. Agents Chemother. 51: 4163-4166 [Abstract] [Full Text]  
  • Amyes, S. G. B., Walsh, F. M., Bradley, J. S. (2007). Best in class: a good principle for antibiotic usage to limit resistance development?. J Antimicrob Chemother 59: 825-826 [Abstract] [Full Text]  
  • DeRyke, C. A., Du, X., Nicolau, D. P. (2006). Evaluation of bacterial kill when modelling the bronchopulmonary pharmacokinetic profile of moxifloxacin and levofloxacin against parC-containing isolates of Streptococcus pneumoniae. J Antimicrob Chemother 58: 601-609 [Abstract] [Full Text]  
  • Wang, Y. C., Lipsitch, M. (2006). Upgrading antibiotic use within a class: Tradeoff between resistance and treatment success. Proc. Natl. Acad. Sci. USA 103: 9655-9660 [Abstract] [Full Text]  
  • Olofsson, S. K., Marcusson, L. L., Komp Lindgren, P., Hughes, D., Cars, O. (2006). Selection of ciprofloxacin resistance in Escherichia coli in an in vitro kinetic model: relation between drug exposure and mutant prevention concentration. J Antimicrob Chemother 57: 1116-1121 [Abstract] [Full Text]  
  • Miller, D., Flynn, P. M., Scott, I. U., Alfonso, E. C., Flynn, H. W. Jr (2006). In vitro fluoroquinolone resistance in staphylococcal endophthalmitis isolates.. Arch Ophthalmol 124: 479-483 [Abstract] [Full Text]  
  • Noreddin, A. M., Haynes, V. L., Zhanel, G. G. (2005). Pharmacokinetics and Pharmacodynamics of the New Quinolones. Journal of Pharmacy Practice 18: 432-443 [Abstract]  
  • Wetzstein, H.-G. (2005). Comparative Mutant Prevention Concentrations of Pradofloxacin and Other Veterinary Fluoroquinolones Indicate Differing Potentials in Preventing Selection of Resistance. Antimicrob. Agents Chemother. 49: 4166-4173 [Abstract] [Full Text]  
  • Marcusson, L. L., Olofsson, S. K., Lindgren, P. K., Cars, O., Hughes, D. (2005). Mutant prevention concentrations of ciprofloxacin for urinary tract infection isolates of Escherichia coli. J Antimicrob Chemother 55: 938-943 [Abstract] [Full Text]  
  • Hermsen, E. D., Hovde, L. B., Konstantinides, G. N., Rotschafer, J. C. (2005). Mutant Prevention Concentrations of ABT-492, Levofloxacin, Moxifloxacin, and Gatifloxacin against Three Common Respiratory Pathogens. Antimicrob. Agents Chemother. 49: 1633-1635 [Abstract] [Full Text]  
  • Campion, J. J., McNamara, P. J., Evans, M. E. (2004). Evolution of Ciprofloxacin-Resistant Staphylococcus aureus in In Vitro Pharmacokinetic Environments. Antimicrob. Agents Chemother. 48: 4733-4744 [Abstract] [Full Text]  
  • Smith, H. J., Walters, M., Hisanaga, T., Zhanel, G. G., Hoban, D. J. (2004). Mutant Prevention Concentrations for Single-Step Fluoroquinolone-Resistant Mutants of Wild-Type, Efflux-Positive, or ParC or GyrA Mutation-Containing Streptococcus pneumoniae Isolates. Antimicrob. Agents Chemother. 48: 3954-3958 [Abstract] [Full Text]  
  • Epstein, B. J, Gums, J. G, Drlica, K. (2004). The Changing Face of Antibiotic Prescribing: The Mutant Selection Window. The Annals of Pharmacotherapy 38: 1675-1682 [Abstract] [Full Text]  
  • Croisier, D., Etienne, M., Piroth, L., Bergoin, E., Lequeu, C., Portier, H., Chavanet, P. (2004). In vivo pharmacodynamic efficacy of gatifloxacin against Streptococcus pneumoniae in an experimental model of pneumonia: impact of the low levels of fluoroquinolone resistance on the enrichment of resistant mutants. J Antimicrob Chemother 54: 640-647 [Abstract] [Full Text]  
  • Croisier, D., Etienne, M., Bergoin, E., Charles, P.-E., Lequeu, C., Piroth, L., Portier, H., Chavanet, P. (2004). Mutant Selection Window in Levofloxacin and Moxifloxacin Treatments of Experimental Pneumococcal Pneumonia in a Rabbit Model of Human Therapy. Antimicrob. Agents Chemother. 48: 1699-1707 [Abstract] [Full Text]  
  • Florea, N. R., Tessier, P. R., Zhang, C., Nightingale, C. H., Nicolau, D. P. (2004). Pharmacodynamics of Moxifloxacin and Levofloxacin at Simulated Epithelial Lining Fluid Drug Concentrations against Streptococcus pneumoniae. Antimicrob. Agents Chemother. 48: 1215-1221 [Abstract] [Full Text]  
  • Wilson, R., Allegra, L., Huchon, G., Izquierdo, J.-L., Jones, P., Schaberg, T., Sagnier, P.-P. (2004). Short-term and Long-term Outcomes of Moxifloxacin Compared to Standard Antibiotic Treatment in Acute Exacerbations of Chronic Bronchitis. Chest 125: 953-964 [Abstract] [Full Text]  
  • Linde, H.-J., Lehn, N. (2004). Mutant prevention concentration of nalidixic acid, ciprofloxacin, clinafloxacin, levofloxacin, norfloxacin, ofloxacin, sparfloxacin or trovafloxacin for Escherichia coli under different growth conditions. J Antimicrob Chemother 53: 252-257 [Abstract] [Full Text]  
  • Joukhadar, C., Stass, H., Muller-Zellenberg, U., Lackner, E., Kovar, F., Minar, E., Muller, M. (2003). Penetration of Moxifloxacin into Healthy and Inflamed Subcutaneous Adipose Tissues in Humans. Antimicrob. Agents Chemother. 47: 3099-3103 [Abstract] [Full Text]  
  • Smith, H. J., Hoban, D. J., Zhanel, G. G. (2003). Reply. J Antimicrob Chemother 52: 732-733 [Full Text]  
  • Schentag, J. J, Meagher, A. K, Forrest, A. (2003). Fluoroquinolone AUIC Break Points and the Link to Bacterial Killing Rates: Part 1: In Vitro and Animal Models. The Annals of Pharmacotherapy 37: 1287-1298 [Abstract] [Full Text]  
  • Allen, G. P., Kaatz, G. W., Rybak, M. J. (2003). Activities of Mutant Prevention Concentration-Targeted Moxifloxacin and Levofloxacin against Streptococcus pneumoniae in an In Vitro Pharmacodynamic Model. Antimicrob. Agents Chemother. 47: 2606-2614 [Abstract] [Full Text]  
  • Fisher, L. M., Gould, K. A., Pan, X.-S., Patel, S., Heaton, V. J. (2003). Analysis of dual active fluoroquinolones in Streptococcus pneumoniae. J Antimicrob Chemother 52: 312-313 [Full Text]  
  • Drlica, K. (2003). The mutant selection window and antimicrobial resistance. J Antimicrob Chemother 52: 11-17 [Abstract] [Full Text]  
  • Lu, T., Zhao, X., Li, X., Hansen, G., Blondeau, J., Drlica, K. (2003). Effect of chloramphenicol, erythromycin, moxifloxacin, penicillin and tetracycline concentration on the recovery of resistant mutants of Mycobacterium smegmatis and Staphylococcus aureus. J Antimicrob Chemother 52: 61-64 [Abstract] [Full Text]  
  • Smith, H. J., Nichol, K. A., Hoban, D. J., Zhanel, G. G. (2003). Stretching the mutant prevention concentration (MPC) beyond its limits. J Antimicrob Chemother 51: 1323-1325 [Full Text]  
  • Kishii, R., Takei, M., Fukuda, H., Hayashi, K., Hosaka, M. (2003). Contribution of the 8-Methoxy Group to the Activity of Gatifloxacin against Type II Topoisomerases of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 47: 77-81 [Abstract] [Full Text]  
  • Hansen, G. T., Metzler, K., Drlica, K., Blondeau, J. M. (2003). Mutant Prevention Concentration of Gemifloxacin for Clinical Isolates of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 47: 440-441 [Full Text]  
  • Smith, H. J., Nichol, K. A., Hoban, D. J., Zhanel, G. G. (2002). Dual activity of fluoroquinolones against Streptococcus pneumoniae: the facts behind the claims. J Antimicrob Chemother 49: 893-895 [Full Text]  
  • Brueggemann, A. B., Coffman, S. L., Rhomberg, P., Huynh, H., Almer, L., Nilius, A., Flamm, R., Doern, G. V. (2002). Fluoroquinolone Resistance in Streptococcus pneumoniae in United States since 1994-1995. Antimicrob. Agents Chemother. 46: 680-688 [Abstract] [Full Text]  
  • Li, X., Zhao, X., Drlica, K. (2002). Selection of Streptococcus pneumoniae Mutants Having Reduced Susceptibility to Moxifloxacin and Levofloxacin. Antimicrob. Agents Chemother. 46: 522-524 [Abstract] [Full Text]  
  • Giamarellou, H. (2002). Prescribing guidelines for severe Pseudomonas infections. J Antimicrob Chemother 49: 229-233 [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»