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Antimicrobial Agents and Chemotherapy, February 2001, p. 601-604, Vol. 45, No. 2
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.2.601-604.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Efficacy of Voriconazole in Treatment of Murine Pulmonary Blastomycosis†

Alan M. Sugar* and Xiu-Ping Liu

Evans Memorial Department of Clinical Research and Department of Medicine, Boston Medical Center, Boston, Massachusetts

Received 16 May 2000/Returned for modification 14 October 2000/Accepted 9 November 2000

We evaluated the efficacy of voriconazole, a new broad-spectrum triazole antifungal compound, in the treatment of murine pulmonary blastomycosis. Since mice metabolize voriconazole rapidly, we took advantage of our previous observation that administration of grapefruit juice to mice resulted in suitable serum voriconazole concentrations so that treatment studies with mice could be done (A. M. Sugar and X.-P. Liu, Med. Mycol. 38:209-121, 2000). Our results show that voriconazole prolonged survival in a dose-dependent fashion and that the fungal burden in the lungs was decreased by voriconazole administered at 40 mg/kg of body weight/day. Voriconazole should be studied in humans with blastomycosis.

* Corresponding author. Mailing address: Boston Medical Center, 650 Albany St., EBRC, Room 627, Boston, MA 02118. Phone: (617) 638-7905. Fax: (617) 414-5280. E-mail: asugar{at}medicine.bu.edu.

dagger Publication 018 from the Collaborative Medical Research Program.

Antimicrobial Agents and Chemotherapy, February 2001, p. 601-604, Vol. 45, No. 2
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.2.601-604.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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