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Antimicrobial Agents and Chemotherapy, February 2001, p. 630-632, Vol. 45, No. 2
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.2.630-632.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Macrolide Resistance in Peptostreptococcus spp. Mediated by ermTR: Possible Source of Macrolide-Lincosamide-Streptogramin B Resistance in Streptococcus pyogenes

Milagro Reig,* Juan-Carlos Galan, Fernando Baquero, and Jose Claudio Perez-Diaz

Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSALUD), 28034 Madrid, Spain

Received 26 July 2000/Returned for modification 13 September 2000/Accepted 19 November 2000

Eighty percent (21 of 26) of macrolide-resistant Peptostreptococcus strains studied harbored the ermTR gene. This methyltransferase gene is also the most frequently found gene among macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes strains. Transfer of the ermTR gene from Peptostreptococcus magnus to macrolide-susceptible S. pyogenes strains indicates that this resistance determinant may circulate among gram-positive aerobic and anaerobic species of the oropharyngeal bacterial flora.

* Corresponding author. Mailing address: Department of Microbiology, Ramón y Cajal Hospital, C. Colmenar km 9, 100, 28034 Madrid, Spain. Phone: (34) 91.336.8330. Fax: (34) 91.336.8809. E-mail: mreig{at}hrc.insalud.es.

Antimicrobial Agents and Chemotherapy, February 2001, p. 630-632, Vol. 45, No. 2
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.2.630-632.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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