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Antimicrobial Agents and Chemotherapy, February 2001, p. 636-638, Vol. 45, No. 2
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.2.636-638.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Mechanisms of Macrolide Resistance in Clinical Pneumococcal Isolates in France

Frederic Fitoussi,1 Catherine Doit,1 Pierre Geslin,2 Naima Brahimi,1 and Edouard Bingen1,*

Service de Microbiologie, Hôpital Robert Debré, 75019 Paris,1 and Centre National de Référence des Pneumocoques, Centre Hospitalier de Créteil, 94010 Créteil,2 France

Received 18 September 2000/Returned for modification 24 October 2000/Accepted 20 November 2000

The genetic basis of macrolide resistance was investigated in a collection of 48 genotypically unrelated clinical isolates of Streptococcus pneumoniae obtained between 1987 and 1997 in France. All strains were resistant to erythromycin, clindamycin, and streptogramin B, exhibiting a macrolide-lincosamide-streptogramin B resistance phenotype, and harbored the erm(B) gene. None of the strains carried the mef(A) or erm(A) subclass erm(TR) gene.

* Corresponding author. Mailing address: Service de Microbiologie, Hôpital R. Debré, 48 Bd Sérurier, 75019 Paris, France. Phone: 33 (1) 40 03 23 40. Fax: 33 (1) 40 03 24 50. E-mail: edouard.bingen{at}rdb.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, February 2001, p. 636-638, Vol. 45, No. 2
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.2.636-638.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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