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Antimicrobial Agents and Chemotherapy, March 2001, p. 943-945, Vol. 45, No. 3
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.3.943-945.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

High-Dose Intravenous Ribavirin Therapy for Subacute Sclerosing Panencephalitis

Mitsuaki Hosoya,1,* Shiro Shigeta,2 Shuichi Mori,2 Akemi Tomoda,3 Seiji Shiraishi,3 Teruhisa Miike,3 and Hitoshi Suzuki1

Department of Pediatrics1 and Microbiology,2 School of Medicine, Fukushima Medical University, Fukushima 960-1295, and Department of Child Development, Kumamoto University School of Medicine, Kumamoto 860-0811,3 Japan

Received 11 July 2000/Returned for modification 11 October 2000/Accepted 30 November 2000

Two patients with subacute sclerosing panencephalitis (SSPE) were treated safely and effectively with high doses of intravenous ribavirin combined with intraventricular alpha interferon. The ribavirin concentrations maintained in the serum and cerebrospinal fluid were higher than those which inhibit SSPE virus replication in vitro and in vivo.

* Corresponding author. Mailing address: Department of Pediatrics, School of Medicine, Fukushima Medical University, Hikarigaoka-1, Fukushima 960-1295, Japan. Phone: (81) 24-548-2111. Fax: (81) 24-548-6578. E-mail: mhosoya{at}fmu.ac.jp.

Antimicrobial Agents and Chemotherapy, March 2001, p. 943-945, Vol. 45, No. 3
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.3.943-945.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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  • Heath, C A, Smith, C, Davenport, R, Donnan, G A (2008). Progressive cognitive decline and myoclonus in a young woman: clinicopathological conference at the Edinburgh Advanced Neurology Course, 2007. PN 8: 296-302 [Full Text]  
  • Hosoya, M., Mori, S., Tomoda, A., Mori, K., Sawaishi, Y., Kimura, H., Shigeta, S., Suzuki, H. (2004). Pharmacokinetics and Effects of Ribavirin following Intraventricular Administration for Treatment of Subacute Sclerosing Panencephalitis. Antimicrob. Agents Chemother. 48: 4631-4635 [Abstract] [Full Text]  
  • Gascon, G. G. (2003). Randomized Treatment Study of Inosiplex Versus Combined Inosiplex and Intraventricular Interferon-{alpha} in Subacute Sclerosing Panencephalitis (SSPE): International Multicenter Study. J Child Neurol 18: 819-827 [Abstract]  
  • Aydin, O. F., Senbil, N., Kuyucu, N., Gurer, Y.K. Y. (2003). Combined Treatment With Subcutaneous Interferon-{alpha}, Oral Isoprinosine, and Lamivudine for Subacute Sclerosing Panencephalitis. J Child Neurol 18: 104-108 [Abstract]  
  • Solomon, T., Hart, C. A., Vinjamuri, S., Beeching, N. J., Malucci, C., Humphrey, P. (2002). Treatment of Subacute Sclerosing Panencephalitis With Interferon-{alpha}, Ribavirin, and Inosiplex. J Child Neurol 17: 703-705 [Abstract]  
  • Garg, R K (2002). Subacute sclerosing panencephalitis. Postgrad. Med. J. 78: 63-70 [Abstract] [Full Text]  


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